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Science 22 September 1972:
Vol. 177. no. 4054, pp. 1116 - 1118
DOI: 10.1126/science.177.4054.1116
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Articles

Axotomy Mimicked by Localized Colchicine Application

Guillermo Pilar 1 and Lynn Landmesser 2

1 Regulatory Biology Section, Biological Sciences Group, University of Connecticut, Storrs 06268
2 Biology Department, Yale University, New Haven, Connecticut

Comparable depression of synaptic transmission in the avian ciliary ganglion resulted from either section or localized colchicine treatment of the ciliary nerves. Both colchicine treatment and axotomny produced similar changes in RNA distribution in the cell bodies as well. Colchicine did not directly affect transmission, and action potential propagation along the ciliary nerves was normal. Interference with axoplasmic transport of material in both cases is postulated to signal the observed chromatolytic changes.


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