Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 22 September 1972:
Vol. 177. no. 4054, pp. 1108 - 1109
DOI: 10.1126/science.177.4054.1108
Prev | Table of Contents | Next

Articles

Inhibition of Angiotensin Conversion in Experimental Renovascular Hypertension

Edward D. Miller Jr 1, Alan I. Samuels 1, Edgar Haber 2, and A. Clifford Barger 3

1 Department of Physiology, Harvard Medical School, Boston, Massachusetts 02115
2 Department of Medicine, Harvard Medical School, and Medical Services, Massachusetts General Hospital, Boston 02114
3 Department of Physiology, Harvard Medical School

Constriction of the renal artery and controlled reduction of renal perfusion pressure is followed by a prompt increase in systemic renin activity and a concomitant rise in blood pressure in trained, unanesthetized dogs. The elevated blood pressure induced by the renal artery stenosis can be prevented by prior treatment with the nonapeptide Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro, which blocks conversion of angiotensin I to angiotensin II. Further, the nonapeptide can restore systemic pressure to normnal in the early phase of renovascular hypertension. These results offer strong evidence that the renin-angiotensin system is responsible for the initiation of hypertension in the unilaterally nephrectomized dog with renal artery constriction.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Angiotensin II Receptor Blockers: A New Class of Antihypertensive Drugs.
M. T. Velasquez (1996)
Arch Fam Med 5, 351-356
   Abstract »    PDF »
Correcting Hypertension Produced by a Solitary Kidney With Renal Artery Stenosis by A utotransplantation.
D. B. Case, M. J. Kleiner, T. G. Pickering, J. C. Whitsell, and J. H. Laragh (1979)
Angiology 30, 351-355
   PDF »
The Role of the Renin-Angiotensin System in the Initiation of Renovascular Hypertension.
A.C. Barger (1976)
Angiology 27, 341-346
   PDF »
Angiotensin-converting enzyme: vascular endothelial localization.
P. Caldwell, B. Seegal, K. Hsu, M Das, and R. Soffer (1976)
Science 191, 1050-1051
   Abstract »    PDF »
Reciprocation of renin dependency with sodium volume dependency in renal hypertension.
H Gavras, H. Brunner, H Thurston, and J. Laragh (1975)
Science 188, 1316-1317
   Abstract »    PDF »
Renin-Angiotensin Role in Thirst: Paradoxical Enhancement of Drinking by Angiotensin Converting Enzyme Inhibitor.
D. Lehr, H. W. Goldman, and P. Casner (1973)
Science 182, 1031-1034
   Abstract »    PDF »
Angiotensin-Sodium Interaction in Blood Pressure Maintenance of Renal Hypertensive and Normotensive Rats.
H. Gavras, H. R. Brunner, E. D. Vaughan Jr., and J. H. Laragh (1973)
Science 180, 1369-1372
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)