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Science 1 September 1972:
Vol. 177. no. 4051, pp. 793 - 795
DOI: 10.1126/science.177.4051.793
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Articles

Bone Resorbing Activity in Supernatant Fluid from Cultured Human Peripheral Blood Leukocytes

John E. Horton 1, Lawrence G. Raisz 2, Hollis A. Simmons 2, Joost J. Oppenheim 3, and Stephan E. Mergenhagen 3

1 U.S. Army Institute of Dental Research, Walter Reed Army Medical Center, Washington, D.C. 20012
2 Departments of Pharmacology and Toxicology and Medicine, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14620
3 Laboratory of Microbiology and Immunology, National Institute of Dental Research, Bethesda, Maryland 20014

A new soluble mediator was found in supernatant fluid from cultures of human peripheral blood leukocytes that were stimulated by phytohemagglutinin, or by antigenic material present in human dental plaque deposits. This soluble Jactor produced bone resorption in organ cultures of fetal rat bones as measured by increased release of calcium-45, and also increased the number of active osteoclasts.


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