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Science 25 August 1972:
Vol. 177. no. 4050, pp. 716 - 718
DOI: 10.1126/science.177.4050.716
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Articles

Genetic Determination of Phenotypic Variation in Sickle Cell Trait

Walter E. Nance 1 and John Grove 1

1 Department of Medical Genetics, Indiana University School of Medicine, Indianapolis 46202

Two genetic sources of variation influence the percentage of sickle cell hemoglobin found in heterozygotes. One factor is strongly related to the percentage of hemoglobin S in the carrier parent and appears to be determined by sickle hemoglobin isoalleles, whereas the other is related to racial background and may well be polygenic.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)