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Science 25 August 1972:
Vol. 177. no. 4050, pp. 709 - 710
DOI: 10.1126/science.177.4050.709
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Articles

Amphotericin B Potentiation of Rifampicin as an Antifungal Agent against the Yeast Phase of Histoplasma capsulatum

G. S. Kobayashi 1, G. Medoff 1, D. Schlessinger 1, C. N. Kwan 1, and W. E. Musser 1

1 Department of Medicine, Divisions of Dermatology and Infectious Diseases, and Department of Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110

Rifampicin, at high concentrations, inhibited growth and RNA synthesis in the yeast phase of Histoplasma capsulatum. These effects were potentiated by low concentrations of amphotericin B. The combination of the two agents was fungicidal, whereas each alone, at much higher concentrations, was only fungistatic.


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