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Science 25 August 1972:
Vol. 177. no. 4050, pp. 705 - 706
DOI: 10.1126/science.177.4050.705
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Articles

Broad-Spectrum Antiviral Activity of Virazole: 1-f8- D-Ribofuranosyl- 1,2,4-triazole- 3-carboxamide

Robert W. Sidwell 1, John H. Huffman 1, G. P. Khare, Lois 1, B. Allen 1, J. T. Witkowski, Roland 1, and K. Robins 1

1 ICN Nucleic Acid Research Institute, Irvine, California 92664

Virazole is a synthetic nucleoside active in tissue culture against at least 16 DNA and RNA viruses. Applied topically, it inhibits herpetic keratitis in rabbits and tail lesions induced by herpes, vaccinia, and vesicular stomatitis viruses in mice. Injected intraperitoneally into mice, it inhibits splenomegaly and hepatomegaly induced by Friend leukemia virus and respiratory infections caused by influenza AO, A2, and B viruses and parainfluenza 1 virus. infections is also effective.


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Ribavirin Treatment of the Acquired Immunodeficiency Syndrome (AIDS) and the Acquired-Immunodeficiency-Syndrome-Related Complex (ARC) A Phase 1 Study Shows Transient Clinical Improvement Associated with Suppression of the Human Immunodeficiency Virus and Enhanced Lymphocyte Proliferation.
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Science 212, 549-551
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