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Science 18 August 1972:
Vol. 177. no. 4049, pp. 633 - 635
DOI: 10.1126/science.177.4049.633
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Articles

Intravenous Injection in Man of Dgr9-Tetrahydrocannabinol and 11-OH-Dgr9-Tetrahydrocannabinol

Mario Perez-Reyes 1, Martha C. Timmons 1, Morrs A. Ipton 1, Kenneth H. Davis 2, and Monroe E. Wall 2

1 Department of Psychiatry, University of North Carolina, School of Medicine, Chapel Hill 27514
2 Chemistry and Life Science Laboratory, Research Triangle Institute, Research Triangle Park, North Carolina 27709

A microsuspension of Dgr9-tetrahydrocannabinol and of its metabolic derivative 11-OH-Dgr9-tetrahydrocannabinol has been prepared with 25 percent human serum albumin as the vehicle. Intravenous infusion of this preparation to humans indicates that both tetrahydrocannabinols are equally potent in producing the typical marihuana-like pschological and physiological effects.


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