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Science 18 August 1972:
Vol. 177. no. 4049, pp. 616 - 617
DOI: 10.1126/science.177.4049.616
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Articles

Neuroanatomical Correlates of Morphine Dependence

Eddie Wei 1, Horace H. Loh 2, and E. Leong Way 3

1 Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley 94720
2 Mendocino State Hospital, Talmage, California
3 Department of Pharmacology, University of California Medical Center, San Francisco 94122

Naloxone hydrochloride, an opioid antagonist, was applied to several discrete brain regions of morphine-dependent rats to precipitate abstinence. Severe withdrawal signs were elicited after administration in the thalamus but not in neocortical, hippocampal, hypothalamic, or tegmental areas of the brain.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neuropeptide Y Attenuates Naloxone-Precipitated Morphine Withdrawal via Y5-like Receptors.
D. P. D. Woldbye, K. Klemp, and T. M. Madsen (1998)
J. Pharmacol. Exp. Ther. 284, 633-636
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Cellular and molecular mechanisms of drug dependence.
G. Koob and F. Bloom (1988)
Science 242, 715-723
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Opiate effects after adrenocorticotropin or beta-endorphin injection in the periaqueductal gray matter of rats.
Y. Jacquet (1978)
Science 201, 1032-1034
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Reversal of Morphine Tolerance after Medial Thalamic Lesions in the Rat.
H. Teitelbaum, G. N. Catravas, and W. L. McFarland (1974)
Science 185, 449-451
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