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Science 21 July 1972:
Vol. 177. no. 4045, pp. 274 - 276
DOI: 10.1126/science.177.4045.274
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Articles

Anemic Stess as a Trigger of Myelogenous Leukemia in the Unirradiated RF Mouse

Joseph K. Gong 1, Paul G. Braunschweiger 1, and Chester A. Glomski 2

1 Department of Oral Biology, School of Dentistry, State University of New York, Buffalo 14214
2 Department of Anatomy, Schools of Dentistry and Medicine, State University of New York, Buffalo

Ninety-six percent of mice that were bled of 50 percent of their blood volume when they were 9 weeks old succumbed to myelogenous leukemia by 15 months after phlebotomy, the majority of them dying between 7 and 10 months after this treatment. These results suggest that (i) anemia is an effective stress for triggering myelogenous leukemia in animals that are predisposed to the disease, (ii) the RF mouse is "naturally" prone to the development of myelogenous leukemia, and (iii) the concept of two-step de novo induction of myelogenous leukemia appears to be applicable in this animal.


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