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Science 21 July 1972:
Vol. 177. no. 4045, pp. 272 - 274
DOI: 10.1126/science.177.4045.272
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Articles

Oligothymidylates: Formation by Thermal Condensation of O2,5'-Cyclothymidine 3'-Phosphate

Joseph Nagyvary 1 and K. L. Nagpal 1

1 Department of Biochemistry and Biophysics, Texas A & M University, College Station 77843

Thermal activation of O2,5'-cyclothymidine 3'-phosphate in solution and in the solid state led to the formation of thymidine oligonucleotides containing up to approximately 12 nucleotide units. Only the 3',5' internucleotide diester bonds were formed. This polymerization occurs without the addition of any activating agent or catalyst.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)