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Science 14 July 1972:
Vol. 177. no. 4044, pp. 178 - 180
DOI: 10.1126/science.177.4044.178
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Articles

Genetics of the Antibody Response to Dextran in Mice

Bonnie Blomberg 1, William R. Geckeler 1, and Martin Weigert 1

1 Salk Institute for Biological Studies, San Diego, California 92112

The immune response to dextran having the agr-1,3 linkage may be under the control of antibody structural genes. Mice that respond well to this antigen produce antibody restricted with respect to light chain class (lgr) and to an antigenic determinant resulting from a particular heavy and light chain interaction. The response to dextran is controlled by a locus linked to the-heavy chain locus.


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