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Science 7 July 1972:
Vol. 177. no. 4043, pp. 62 - 64
DOI: 10.1126/science.177.4043.62
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Articles

11-Hydroxy-Dgr9-tetrahydrocannabinol: Pharmacology, Disposition, and Metabolism of a Major Metabolite of Marihuana in Man

Louis Lemberger 1, Ross E. Crabtree 1, and Howard M. Rowe 1

1 Lilly Laboratory for Clinical Research, Marion County General Hospital, Indianapolis, Indiana 46202

11-Hydroxy-Dgr9-tetrahydrocannabinol, administered intravenously to man, produces psychologic and pharmacologic effects that persist for several hours. The drug and its metabolites are excreted in urine and feces for more than 1 week. The pharmacology, disposition, and metabolism of 11-hydroxy-Dgr9-tetra-hydrocannabinol mimic that of Dgr9-tetrahydrocannabinol, thus providing evidence that Dgr9-tetrahydrocannabinol (the major active component of marihuana) is converted to the 11-hydroxy compound in man, the latter compound being responsible for the effects.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
{Delta}9-Tetrahydrocannabinol (THC), 11-Hydroxy-THC, and 11-Nor-9-carboxy-THC Plasma Pharmacokinetics during and after Continuous High-Dose Oral THC.
E. W. Schwilke, D. M. Schwope, E. L. Karschner, R. H. Lowe, W. D. Darwin, D. L. Kelly, R. S. Goodwin, D. A. Gorelick, and M. A. Huestis (2009)
Clin. Chem. 55, 2180-2189
   Abstract »    Full Text »    PDF »
Intravenously Injected Marihuana Syndrome.
S. J. Farber and V. E. Huertas (1976)
Arch Intern Med 136, 337-339
   Abstract »    PDF »
Dgr9-Tetrahydrocannabinol: Effects on Mammalian Nonmyelinated Nerve Fibers.
R. Byck and J. M. Ritchie (1973)
Science 180, 84-85
   Abstract »    PDF »
Delta-9-Tetrahydrocannabinol: Localization in Body Fat.
D. S. Kreuz and J. Axelrod (1973)
Science 179, 391-393
   Abstract »    PDF »


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