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Science 7 July 1972:
Vol. 177. no. 4043, pp. 60 - 61
DOI: 10.1126/science.177.4043.60
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Articles

Inhibition of Chemical Carcinogenesis by Viral Vaccines

Carrie E. Whitmire 1 and Robert J. Huebner 2

1 Department of Viral-Chemical Oncology, Microbiological Associates, Inc., 4733 Bethesda Avenue, Bethesda, Maryland 20014
2 Viral Carcinogenesis Branch, National Cancer Institute, Bethesda, Maryland 20014

The incidence of 3-methylcholanthrene-induced subcutaneous tumors was significantly reduced by a single injection of inactivated type C RNA viral vaccine. Rauscher leukemia virus vaccine reduced the incidence of sarcomas from 78 to 50 percent in the BALB/cCr mouse. Radiation leukemia virus vaccine and a vaccine from a wild murine leukemia virus derived from a 3-methylcholanthrene tumor reduced the incidence of sarcoma from 86 percent to 33 and 37 percents, respectively, in the C57BL/6 mouse. These reductions in tumor incidence by virus vaccines help support the concept that type C RNA viruses serve as determinants of chemically induced cancer; additional studies of vaccines made with more purified virus preparations are necessary.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Murine C-type RNA Virus from Spontaneous Neoplasms: in vitro Host Range and Oncogenic Potential.
R. L. Peters, G. J. Spahn, L. S. Rabstein, G. J. Kelloff, and R. J. Huebner (1973)
Science 181, 665-667
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