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Science 30 June 1972:
Vol. 176. no. 4042, pp. 1420 - 1422
DOI: 10.1126/science.176.4042.1420
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Articles

Spontaneous Transformation of Human Brain Cells Grown in vitro and Description of Associated Virus Particles

John Hooks 1, C. J. Gibbs Jr. 1, H. Chopra 2, M. Lewis 3, and D. C. Gajdusek 3

1 National Institute of Neurological Diseases anzd Stroke, Bethesda, Maryland 20014
2 National Cancer Institute, Bethesda, Maryland 20014
3 National Institute of Nelurological Diseases and Stroke, Bethesda, Maryland 20014

A human brain cell culture grown in vitro has spontaneously transformed, as determined by morphology, growth characteristics, and karyotype analysis. Virus particles morphologically akin to oncogenic RNA viruses are present in the transformed cells, which are now in subculture 60.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Transformation of Cell Cultures Derived from Human Brains.
M. Katz, H. Koprowski, P. S. Moorhead, J. J. Hooks, C. J. Gibbs Jr., and D. C. Gajdusek (1973)
Science 179, 1019-1020
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