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Science 23 June 1972:
Vol. 176. no. 4041, pp. 1324 - 1325
DOI: 10.1126/science.176.4041.1324
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Articles

Autosensitization of Lymphocytes against Thymus Reticulum Cells

Irun R. Cohen 1 and Hartmut Wekerle 1

1 Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel

Lymph nodes of normal rats contain lymphocytes that can be induced in vitro to mediate a specific cellular immune reaction against reticulum cells derived from syngeneic adult thymus glands. It is likely that these lymphocytes had access to reticulum cell antigens during the period in which they developed immunocompetence within the thymus. This suggests that contact with self-antigens during development may not eliminate self-reactive lymphocytes. These findings are in conflict with the theory that natural tolerance to self-antigens depends upon elimination of lymphocyte clones.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Autoimmune Encephalomyelitis: Activation of Thymus Lymphocytes against Syngeneic Brain Antigens in vitro.
S. Orgad and I. R. Cohen (1974)
Science 183, 1083-1085
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