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Science 16 June 1972:
Vol. 176. no. 4040, pp. 1247 - 1248
DOI: 10.1126/science.176.4040.1247
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Articles

5,6-Trans-25-Hydroxycholecalciferol: Vitamin D Analog Effective on Intestine of Anephric Rats

M. F. Holick 1, M. Garabedian 1, and H. F. DeLuca 1

1 Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin, Madison 53706

A new compound, 5,6-trans-25-hydroxycholecalciferol, has been synthesized and tested for its biological activity. Like 1,25-dihydroxycholecalciferol, it stimulates intestinal calcium transport in anephric rats, whereas 25-hydroxycholecalciferol does not. But this analog has little if any activity in stimulating mobilization of calcium from the bone of anephric rats.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Calcium Absorptive Effects of Vitamin D and Its Major Metabolites.
R. P. Heaney, M. J. Barger-Lux, M. S. Dowell, T. C. Chen, and M. F. Holick (1997)
J. Clin. Endocrinol. Metab. 82, 4111-4116
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Calcifediol in Chronic Renal Insufficiency.
J. W. Coburn and A. W. Norman (1976)
JAMA 236, 347
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Vitamin D: 3-deoxy-lalpha-hydroxyvitamin D3, biologically active analog of lalpha-dihydroxyvitamin D3.
A. Norman, M. Mitra, W. Okamura, and R. Wing (1975)
Science 188, 1013-1015
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Isotachysterol3 and 25-Hydroxyisotachysterol3: Analogs of 1,25-Dihydroxyvitamin D3.
M. F. Holick, H. F. DeLuca, P. M. Kasten, and M. B. Korycka (1973)
Science 180, 964-966
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