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Science 9 June 1972:
Vol. 176. no. 4039, pp. 1135 - 1136
DOI: 10.1126/science.176.4039.1135
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Articles

Age Changes in the Neuronal Microenvironment

William Bondari 1 and Robert Narot 1

1 Department of Anatomy, Northwestern University Medical School, Chicago, Illinois 60611

The extracellular space of the rat brain was visualized by electron roscopy in sections of cerebral cortex fixed by freeze-substitution. The volume tissue occupied by the extracellular space was estimated stereomnetrically, and found to decrease from 20.8 percent in 3-month-old rats to 9.6 percent in escent animals, 26 months of age. This decrease in extracellular space indicates age-associated change in the microenvironment of nerve cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Diffusion in Brain Extracellular Space.
E. Sykova and C. Nicholson (2008)
Physiol Rev 88, 1277-1340
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Science. ISSN 0036-8075 (print), 1095-9203 (online)