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Science 2 June 1972:
Vol. 176. no. 4038, pp. 1039 - 1041
DOI: 10.1126/science.176.4038.1039
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Articles

Stimulation by Phagocytosis of the Deiodination of l-Thyroxine in Human Leukocytes

Kenneth A. Woeber 1, Gail F. Doherty 1, and Sidney H. Ingbar 1

1 Harvard Medical Unit, Boston City Hospital, Boston, Massachusetts 02118

Intact human leukocytes actively deiodinate L-[1311] thyroxine, producing mainly inorganic 1311 and chromatographically immobile 1311-labeled origin material. When phagocytosis is induced, the deiodination is enhanced, a suggestion that deiodination in mediated by a peroxidase-hydrogen peroxide system. l-Thyroxine can serve as a source of iodine for iodination reactions within the leukocyte.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Singlet Excited Oxygen as a Mediator of the Antibacterial Action of Leukocytes.
N. I. Krinsky (1974)
Science 186, 363-365
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