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Science 2 June 1972:
Vol. 176. no. 4038, pp. 1031 - 1033
DOI: 10.1126/science.176.4038.1031
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Articles

Carbonic Anhydrase and Bone Remodeling: Sulfonamide Inhibition of Bone Resorption in Organ Culture

Cedric Minkin 1 and Joan M. Jennings 1

1 Department of Periodontology, Harvard School of Dental Medicine, Boston. Massachusetts 02115

Five sulfonamide inhibitors of carbonic anhydrase inhibited parathyroid hormone-induced resorption of bone in organ culture. The relative activities of the sulfonamides as resorption inhibitors were such as to suggest the presence of a functional carbonic anhydrase system in bone linked to the mechanism of bone resorption.


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Carbonic Anhydrase and Osteoclasts: Localization by Labeled Inhibitor Autoradiography.
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Ann Intern Med 78, 365-369
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