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Science 5 May 1972:
Vol. 176. no. 4034, pp. 528 - 530
DOI: 10.1126/science.176.4034.528
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Articles

Receptor-Estrogen Complex in the Nuclear Fraction of Rat Uterine Cells during the Estrous Cycle

J. H. Clark 1, J. Anderson 1, and E. J. Peck Jr. 1

1 Department of Biological Sciences, Purdue University, Lafayette, Indiana 47907

A quantitative method was used to determine the concentration of receptor-estrogen complex in the nuclear fraction of rat uterine cells throughout the estrous cycle. The concentrations of nuclear receptor-estrogen complex were: metestrus, 0.22; diestrus, 0.75; proestrus, 1.29; and estrus, 0.31 picomoles per milligram of DNA. This cyclic fluctuation in the nuclear complex closely parallels the secretion of ovarian estrogen during the estrous cycle, an indication that the accumulation of receptor-estrogen complex by the nuclear fraction of uterine cells may be of physiological significance, and under the control of endogenous estrogen.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Estrogen receptors in the nidatory sites of the rat endometrium.
D Martel and A Psychoyos (1981)
Science 211, 1454-1455
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Female Steroid Hormones and Target Cell Nuclei: The effects of steroid hormones on target cell nuclei are of major importance in the induction of new cell functions.
B. W. O'Malley and A. R. Means (1974)
Science 183, 610-620
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