Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 5 May 1972:
Vol. 176. no. 4034, pp. 525 - 526
DOI: 10.1126/science.176.4034.525
Prev | Table of Contents | Next

Articles

Methadone Binding to Human Plasma Albumin

George D. Olsen 1

1 University of Oregon Medical School, Portland 97201

The interaction of L-[1-3H] methadone with human plasma albumin was studied by equilibrium dialysis. The percent of methadone bound to albumin was relatively independent of the concentration of methadone, but was dependent on the concentration of albumin, ranging from 8.0 to 43.8 percent bound as the albumin concentration increased from 0.400 gram to 5.00 grams per 100 milliliters of solution.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Effect of Sodium Salicylate and Indomethacin on Methotrexate-Serum Albumin Binding.
J. R. Taylor and K. M. Halprin (1977)
Arch Dermatol 113, 588-591
   Abstract »    PDF »
Blood-Brain Barrier: Penetration of Morphine, Codeine, Heroin, and Methadone after Carotid Injection.
W. H. Oldendorf, S. Hyman, L. Braun, and S. Z. Oldendorf (1972)
Science 178, 984-986
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)