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Science 28 April 1972:
Vol. 176. no. 4033, pp. 417 - 418
DOI: 10.1126/science.176.4033.417
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Articles

Ergot-Induced Inhibition of Pituitary Tumor Growth in Rats

S. K. Quadri 1, K. H. Lu 1, and J. Meites 1

1 Department of Physiology, Michigan State University, East Lansing 48823

Daily injections of ergocornine or ergonovine, for 3 weeks, into rats carrying a prolactin- and growth hormone—secreting pituitary tumor (MtW15) induced significant regression or inhibition of tumor growth, whereas ergocryptine had no significant effect. Ergocornine caused a decrease in cells and a disappearance or pycnosis of nuclei in the tumor tissue, and a reduced concentration of prolactin in blood.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Size Reduction of Extrasellar Pituitary Tumors During Bromocriptine Treatment: Quantitation of Effect on Different Types of Tumors.
F. WOLLESEN, T. ANDERSEN, and A. KARLE (1982)
Ann Intern Med 96, 281-286
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