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Science 21 April 1972:
Vol. 176. no. 4032, pp. 308 - 309
DOI: 10.1126/science.176.4032.308
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Articles

Neuromuscular Transmission: Inhibition by Manganese Ions

U. Meiri 1 and R Rahamimoff 1

1 Department of Physiology, Hebrew University-Hadassah Medical School, P. O. Box 1172, Jerusalem, Israel

Manzganiese ions. are potent blocking argenits of synaptic transmission at the neuromuscular junction in the frog. The main site of action is the presynaptic nerve terminal, where the ions decr-ease the amount of transmitter liberated by a never impulse. The inihibition produced by manganese is reversible.


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