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Science 31 March 1972:
Vol. 175. no. 4029, pp. 1479 - 1480
DOI: 10.1126/science.175.4029.1479
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Articles

GABA Catabolism: Localization of Succinic Semialdehyde Dehydrogenase in Brain Motor and Sensory Nuclei

K. L. Sims 1, H. A. Weitsen 1, and F. E. Bloom 1

1 Laboratory of Neuropharmacology, Division of Special Mental Health Research, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032

The localization of brain succinic semialdehyde dehydrogenase, a specific gamma-aminobutyric acid degradative enzyme, could potentially yield valuable information concerning the function of the enzyme. Application of a new histochemical technique for this enzyme has revealed characteristic patterns of neuronal staining that are contsistent within embryologically and functionally similar nuclei of the brainstem of the rat.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)