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Science 31 March 1972:
Vol. 175. no. 4029, pp. 1473 - 1475
DOI: 10.1126/science.175.4029.1473
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Articles

Transfer Factor from Guinea Pigs Sensitive to Dinitrochlorobenzene: Absence of Superantigen Properties

Denis R. Burger 1, R. Mark Vetto 1, and Arthur Malley 2

1 Surgical Research Laboratory, Veterans Administration Hospital, and Department of Microbiology and Surgery, University of Oregon Medical School, Portland 97207
2 Department of Immunology, Oregon Regional Primate Research Center, Beaverton 97005

Transfer factor from guinea pigs sensitive to dinitrochlorobenzene was not bound to an immunoadsorbent column that is specific for the dinitrophenyl determinant. The absence of the dinitrophenyl determinant on transfer factor suggested that the factor does not function as superantigen. The duration of the adoptive sensitivity, the small molecular weight, and the polypeptide or polynucleotide (or a combination) composition of the transfer factor are consistent with a derepressor function of the molecule.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)