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Science 17 March 1972:
Vol. 175. no. 4027, pp. 1264 - 1266
DOI: 10.1126/science.175.4027.1264
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Articles

Messenger RNA Structure: Compatibility of Hairpin Loops with Protein Sequence

Harold B. White III 1, Brian E. Laux 1, and Don Dennis 1

1 Department of Chemistry, University of Delaware, Newark 19711

Examination of the amino acid sequences of human cytochrome c and the agr-chain variant of human hemoglobin Constant Spring has revealed the possiblity for base-paired hairpin loops in the messenger RNA's for these proteins. A similar analysis of the bacteriophage R17 coat protein suggests an additional unobserved loop in the R17 RNA. If such loops are present in messenger RNA's generally, it would suggest that DNA has more than one stable base-paired conformation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A periodic pattern of mRNA secondary structure created by the genetic code..
S. A. Shabalina, A. Y. Ogurtsov, and N. A. Spiridonov (2006)
Nucleic Acids Res. 34, 2428-2437
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Science. ISSN 0036-8075 (print), 1095-9203 (online)