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Science 3 March 1972:
Vol. 175. no. 4025, pp. 1010 - 1011
DOI: 10.1126/science.175.4025.1010
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Articles

Lack of Enhanced Oxygen Consumption by Polymorphonuclear Leukocytes on Phagocytosis of Virulent Salmonella typhi

Roger M. Miller 1, Joel Garbus 2, and Richard B. Hornick 3

1 Center for the Study of Trauma, Department of Surgery, and Division of Infectious Diseases, University of Maryland, Baltimore 21201
2 Center for the Study of Trauma, Department of Surgery, University of Maryland, Baltimore
3 Division of Infectious Diseases, University of Maryland, Baltimore

Human polymorphonuclear leukocytes exhibit an enhanced rate of oxygen consumption during phagocytosis of relatively avirulent strains of Salmonella typhi or Staphylococcus aureus. However, phagocytosis of a virulent strain of Salmonella typhi is not associated with augmented oxygen consumption. The ability of a bacterial strain to alter the postphagocytic rate of oxygen consumption of polymorphonuclear leukocytes may be related to its in vivo virulence.


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