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Science 3 March 1972:
Vol. 175. no. 4025, pp. 1002 - 1003
DOI: 10.1126/science.175.4025.1002
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Articles

Human Phosphoglycerate Kinase and Inactivation of the X Chromosome

B. F. Deys 1, K. H. Grzeschick 1, A. Grzeschick 1, E. R. Jaffé 1, and M. Siniscalco 1

1 Department of Genetics, Division of Biological Sciences; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461

The fibroblasts derived from the skin of a woman heterozygous for an X-linked deficiency of phosphoglycerate kinase represented a mosaic. Two of 22 clones with normal glucose-6-phosphate dehydrogenase activity and hypoxanthine(guanine) phosphoribosyltransferase activity had no phosphoglycerate kinase activity detected by electrophoresis. Because the loci for glucose-6-phosphate dehydrogeniase and hypoxanthine(guanine)phosphoribosyltransferase are already known to undergo inactivation and to be on the short arm of the X chromosome and the locus for phosphoglycerate kinase is on the long arm, these observations support the conclusion that the entire human X chromosome can be involved in X inactivation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Non-inactivation of an x-chromosome locus in man.
L. Shapiro, T Mohandas, R Weiss, and G Romeo (1979)
Science 204, 1224-1226
   Abstract »    PDF »
Conservation of Ancient Linkage Groups in Evolution and Some Insight into the Genetic Regulatory Mechanism of X-inactivation.
S. Ohno (1974)
Cold Spring Harb Symp Quant Biol 38, 155-164
   Abstract »    PDF »


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