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Science 25 February 1972:
Vol. 175. no. 4024, pp. 905 - 906
DOI: 10.1126/science.175.4024.905
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Articles

Turnover of Molecules Which Maintain the Normal Surfaces of Contact-Inhibited Cells

Joffre B. Baker 1 and Tom Humphreys 1

1 Department of Biology, University of California at San Diego, La Jolla 92037

In confluent cultures normal chick embryo fibroblasts become highty agglutinable by concanavalin A within 6 hours after their synthesis of protein is inhibited by cycloheximide, pactamycin, or emetine. When growing cells are similarly treated, they fail to become more agglutinable. Apparently, molecules which maintain the normal structure of the cell surface must be replaced continually when cell growth is contact inhibited.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)