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Science 18 February 1972:
Vol. 175. no. 4023, pp. 774 - 776
DOI: 10.1126/science.175.4023.774
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Articles

Cytochalasin B: Does It Affect Actin-Like Filaments?

Arthur Forer 1, J. Emmersem 1, and O. Behnke 2

1 Department of Molecular Biology, Odense University, Odense, Denmark
2 Anatomy Institute C, Copenhagen University, Copenhagen, Denmark

An in vitro system was used to test the purported action of cytochalasin B. At concentrations 100 times those used for experiments in vivo, cytochalasin B did not cause the breakdown of F-actin, did not inhibit the transformation of G-actin to F-actin, did not inhibit the binding of heavy meromyosin to F-actin, and did not inhibit the adenosine triphosphate-induced release of heavy meromyosin from F-actin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Selected Topics in Skeletal Myogenesis.
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Effects of Cytochalasin B on Actin Filaments.
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