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Science 18 February 1972:
Vol. 175. no. 4023, pp. 766 - 768
DOI: 10.1126/science.175.4023.766
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Articles

Tissue Factor (Thromboplastin): Localization to Plasma Membranes by Peroxidase-Conjugated Antibodies

Steven M. Zeldis 1, Yale Nemerson 1, Frances A. Pitlick 1, and Thomas L. Lentz 2

1 Departmnent of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510
2 Department of Anatomy, Yale University School of Medicine

Peroxidase-conjugated antibodies were used to determine the histologic and cytologic localization of bovine and human tissue factor (thromboplastin). Tissue factor antigen was found in highest concentration in the intima of blood vessels, particularly in the plasma membranes of endothelial cells and in human atheromatous plaques. Tissue factor was also found limited to the plasma membranes of many cell types. The presence of tissue factor in the plasma membranes of endothelial cells and atheromata suggests that it may play a significant role in hemostasis and thrombosis.


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