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Science 11 February 1972:
Vol. 175. no. 4022, pp. 650 - 652
DOI: 10.1126/science.175.4022.650
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Articles

Externally Suppressible Proline Quadruplet CCCUU

Joseph Yourno 1 and Tadahiko Kohno 1

1 Biology Department, Brookhaven National Laboratory, Upton, New York 11973

Three (+1) frameshift mutations located at different genetic sites respond with high specificity to the same external suppressor. In each case, the suppressor restores small amounts of protein that is normal in electrophoretic mobility and heat stability. One of these proteins has been shown to have the wildtype amino acid sequence. The messenger RNA quadruplet CCCUUappears to be common to all three frameshift sites and to be translated by the suppressor as proline. A likely suppressor agent is a proline transfer RNA with a quadruplet anticodon or its functional equivalent.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Prevention of translational frameshifting by the modified nucleoside 1-methylguanosine.
G. Bjork, P. Wikstrom, and A. Bystrom (1989)
Science 244, 986-989
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Suppressible four-base glycine and proline codons in yeast.
T. Donahue, P. Farabaugh, and G. Fink (1981)
Science 212, 455-457
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Science. ISSN 0036-8075 (print), 1095-9203 (online)