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Science 4 February 1972:
Vol. 175. no. 4021, pp. 547 - 550
DOI: 10.1126/science.175.4021.547
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Articles

Dgr9-Tetrahydrocannabinol: Dose-Related Effects on Timing Behavior in Chimpanzee

Donald G. Conrad 1, Timothy F. Elsmore 1, and Frank J. Sodetz 1

1 Department of Experimental Psychology, Walter Reed Army Institute of Research, Washington, D. C. 20012

Dgr9-Tetrahydrocannabinol, at doses within the effective range for humans, was administered orally to chimpanzees with stable, efficient timing performances maintained by multilink chained schedules of food reinforcement. Reinforcements decreased with increasing dose, because of decreased frequencies of total operant timing responses and decreased accuracy of the timing performances which did occur. Higher doses exerted an effect for up to 3 days.


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G. Y. H. Mcclure and D. E. Mcmillan (1997)
J. Pharmacol. Exp. Ther. 281, 1368-1380
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delta9-tetrahydrocannabinol: antiaggressive effects in mice, rats, and squirrel monkeys.
K. Miczek (1978)
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Lack of Tolerance to Dgr9-Tetrahydrocannabinol in Chimpanzees.
D. P. Ferraro and D. M. Grilly (1973)
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Science. ISSN 0036-8075 (print), 1095-9203 (online)