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Science 14 January 1972:
Vol. 175. no. 4018, pp. 192 - 194
DOI: 10.1126/science.175.4018.192
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Articles

Sulfatide Synthesis: Inhibition by Experimental Allergic Encephalomyelitis Serum

June M. Fry 1, Gerard M. Lehrer 1, and Murray B. Bornstein 2

1 Department of Neurology, Division of Neurochemistry, Mount Sinai School of Medicine of the City University of New York, New York 10029
2 Saul R. Korey Department of Neurology, Albert Einstein College of Medicine of Yeshiva University, New York 10461

The rate of 35S incorporation into cerebroside sulfate in cultures of embryo mouse spinal cord shows a rapid acceleration at the time of myelin formation. Exposure of cultures to dilute serum from rabbits with experimental allergic encephalomyelitis results in almost complete inhibition of sulfatide synthesis. Within 24 hours after replacement of inhibiting medium with normal medium there is an increase in sulfatide synthesis followed by myelination.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cerebroside Antibody Inhibits Sulfatide Synthesis and Myelination and Demyelinates in Cord Tissue Cultures.
J. M. Fry, S. Weissbarth, G. M. Lehrer, and M. B. Bornstein (1974)
Science 183, 540-542
   Abstract »    PDF »
Myelination Inhibition Factor: Dissociation from Induction of Experimental Allergic Encephalomyelitis.
M. W. Kies, B. F. Driscoll, F. J. Seil, and E. C. Alvord Jr. (1973)
Science 179, 689-690
   Abstract »    PDF »


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