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Science 14 January 1972:
Vol. 175. no. 4018, pp. 182 - 185
DOI: 10.1126/science.175.4018.182
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Articles

Human Sarcomas Contain RNA Related to the RNA of a Mouse Leuemia Virus

D. Kufe 1, R. Hehlmann 1, and S. Spiegelman 1

1 Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New York 10032

Labeled DNA complementary to the RNA of the Rauscher leukemia virus was hybridized with RNA from the polysome fraction of human sarcomas. Eighteen out of 25 specimens contained RNA possessing homology to the RNA of the mouse leukemia virus but not to that of the unrelated viruses causing mammary tumors in mice or myeloblastosis in chickens. Further, no normal adult or fetal tissues showed significant amounts of RNA specific to mouse leukemia virus. It appears that human sarcomas contain RNA sequences homologous to those found in an agent related to a virus known to cause sarcomas in mice.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Ribonucleic Acid: I. The Test-Tube Synthesis of a Viral Nucleic Acid II. The Development and Use of Molecular Hybridization.
S. Spiegelman (1974)
JAMA 230, 1036-1042
   Abstract »    PDF »
Cytotoxic Antibody in Normal Human Serums Reactive with Tumor Cells from Acute Lymphocytic Leukemia.
W. B. Bias, G. W. Santos, P. J. Burke, G. M. Mullins, and R. L. Humphrey (1972)
Science 178, 304-306
   Abstract »    PDF »


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