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Science 14 January 1972:
Vol. 175. no. 4018, pp. 175 - 176
DOI: 10.1126/science.175.4018.175
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Articles

Copper on Intrauterine Devices Stimulates Leukocyte Exudation

Alvaro Cuadros 1 and James G. Hirsch 1

1 Population Council and Rockefeller University, New York 10021

Metallic copper in the uterine or abdominal cavities of rats or monkeys stimulates an impressive local exudation of polymorphonuclear leukocytes. This cellular response to copper persists for at least 7 months, without significant local tissue damage or detectable systemic effects on the test animal. This finding provides a possible explanation for the capacity of copper to increase impressively the antifertility effect of polyethylene intrauterine contraceptive devices.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Chalcosis in the Human Eye: A Clinicopathologic Study.
N. A. Rao, M. O. M. Tso, and A. R. Rosenthal (1976)
Arch Ophthalmol 94, 1379-1384
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Science. ISSN 0036-8075 (print), 1095-9203 (online)