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Science 7 January 1972:
Vol. 175. no. 4017, pp. 67 - 68
DOI: 10.1126/science.175.4017.67
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Articles

Mechanism of Gonadotropin Action in Amphibia: Involvement of Mitochondria

John P. Wiebe 1

1 Department of Biology, Texas A&M University, College Station 77843

Luteinizing hormone (a pituitary gonadotropic hormone) stimulates Dgr5-3beta- hydroxysteroid dehydrogenase activity in the microsomal fraction of frog testes when incubated together with the mitochondria; incubation together with the nuclei instead of the mitochondria does not result in increased, Dgr5-3beta-hydroxysteroid dehydrogenase activity. The increase is not, induced by adenosine triphosphate, it appears to be hormone-specific, and it is sensitive to puromycin and actinomycin D. These data suggest that the mitochondrial DNA may be involved in mediating the action of luteinizing hormone in amphibian steroidogenesis.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)