Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 24 December 1971:
Vol. 174. no. 4016, pp. 1339 - 1341
DOI: 10.1126/science.174.4016.1339
Prev | Table of Contents | Next

Articles

Selection of Ribosomal Mutants by Antibiotic Suppression in Yeast

Frank T. Bayliss 1 and Robert T. Vinopal 1

1 Department of Bacteriology, University of California, Davis 95616

Wild-type Saccharomyces cerevisiae is highly resistant to streptomycin. A histidine auxotroph was found which could grow without histidine in the presence of high concentrations of streptomycin. Selection for derivatives of this strain which could be suppressed by much lower concentrations of streptomycin yielded streptomycin-sensitive mutants which are cold-sensitive and have altered ribosomal profiles.

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)