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Science 17 December 1971:
Vol. 174. no. 4015, pp. 1245 - 1247
DOI: 10.1126/science.174.4015.1245
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Articles

Ethanol Stimulates Triglyceride Synthesis by the Intestine

Edward A. Carter 1, Gladys D. Drummey 1, and Kurt J. Isselbacher 1

1 Department of Medicine, Harvard Medical School, and Massachusetts General Hospital, Boston 02114

In vivo ethanol given acutely or chronically by two dietary means resulted in significant increases in [1-14C]palmitate incorporation into triglyceride by intestinal slices or microsomes derived from intestinal slices. In vitro, 2.6 percent ethanol, an amount comparable to that found in t..e intestinal lumen of social drinkers, also resulted in significant increases in [1-14C]palmitate incorporation into triglyceride. Pyrazole, an inhibitor of alcohol dehydrogenase, diminished the stimulatory effect of ethanol both in vivo and in vitro. These data may provide a new insight into the effects of alcohol, and specifically on the possible contribution of intestinal triglyceride synthesis to alcoholic hyperlipemia and the alcohol-induced fatty liver.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Ethanol Oxidation: Effect on the Redox State of Brain in Mouse.
A. K. Rawat and K. Kuriyama (1972)
Science 176, 1133-1135
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Science. ISSN 0036-8075 (print), 1095-9203 (online)