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Science 10 December 1971:
Vol. 174. no. 4014, pp. 1136 - 1137
DOI: 10.1126/science.174.4014.1136
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Articles

Detection of an Antigen Associated with Acute Leukemia

Dean L. Mann 1, G. Nicholas Rogentine 1, Rober Halterman 1, and Brigid Leventhal 1

1 Immunology Branch and Leukemia Service, National Cancer Institute, Bethesda, Maryland 20014

Antiserums to a purified cell membrane component from a Burkitt's lymphoma tissue culture cell line were produced in rabbits. These antiserums were cytotoxic to peripheral white blood cells from 8 of 15 patients with acute leukemia and 5 of 41 relatives, but not to peripheral white blood cells from leukemia patients in clinical remission or from normal individuals. These antiserums appear to be detecting an acute leukemia associated antigen or antigens.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Immunotherapy and Human Tumor Immunology.
J. L. FAHEY, S. BROSMAN, R. C. OSSORIO, C. O'TOOLE, and J. ZIGHELBOIM (1976)
Ann Intern Med 84, 454-465
   Abstract »    PDF »
Cytotoxic Antibody in Normal Human Serums Reactive with Tumor Cells from Acute Lymphocytic Leukemia.
W. B. Bias, G. W. Santos, P. J. Burke, G. M. Mullins, and R. L. Humphrey (1972)
Science 178, 304-306
   Abstract »    PDF »


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