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Science 10 December 1971:
Vol. 174. no. 4014, pp. 1134 - 1136
DOI: 10.1126/science.174.4014.1134
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Articles

Human Leukemic Cells: In vitro Growth of Colonies Containing the Philadelphia (Ph1) Chromosome

Paul A. Chervenick 1, Lawrence D. Ellis 1, Sylvia F. Pan 1, and Alton L. Lawson 1

1 University of Pittsburgh School of Medicine and Graduate School of Public Health, Department of Medicine and Radiation Health, Pittsburgh, Pennsylvania 15213

Human leukemic cells with a marker (Philadelphia; Ph1) chromosome gave rise to granulocytic and mononuclear cell colonies when grown in vitro. All metaphases from a single colony were either Ph1 positive or Ph1 negative. No colonies contained a mixed cell population. This suggests that leukemic and normal cells exist simultaneously and that in vitro colonies are clonal in origin.


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Blood 89, 2623-2634
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Granulocytes in Human Disease.
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Ann Intern Med 81, 801-816
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Human Blood Monocytes: Stimulators of Granulocyte and Mononuclear Colony Formation in vitro.
P. A. Chervenick and A. F. LoBuglio (1972)
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