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Science 3 December 1971:
Vol. 174. no. 4013, pp. 1029 - 1031
DOI: 10.1126/science.174.4013.1029
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Articles

Potassium Ion Release and Enzyme Secretion: Adrenergic Regulation by agr-and beta-Receptors

Samuel Batzri 1, Zvi Selinger 1, and Michael Schramm 1

1 Department of Biological Chemistry, Hebrew University of Jerusalem, Jerusalem, Israel

Epinephrine caused amylase secretion and K+ release in rat parotid slices. Propranolol, which blocks beta-receptors, inhibited amylase secretion; phentolamine, which blocks agr-receptors, inhibited K+ release. Since enzyme secretion was associated with fusion of secretory granules to the cell membrane and K+ release was associated with vacuole formation, it could be shown that both agr- and beta-receptors are present in the same exocrine cell. The findings appear to exclude cyclic 3',5'-adenosine monophosphate as an intermediate in the agr-receptor response.


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