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Science 19 November 1971:
Vol. 174. no. 4011, pp. 838 - 839
DOI: 10.1126/science.174.4011.838
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Articles

Neuronal GM1 Gangliosidosis in a Siamese Cat with beta-Galactosidase Deficiency

Henry J. Baker Jr. 1, J. Russell Lindsey 1, Guy M. McKhann 2, and Donald F. Farrell 2

1 Department of Comparative Medicine, Schools of Medicine and Dentistry, University of Alabama in Birmingham, and Veterans Administration Hospital, Birmingham 35233
2 Department of Neurology, Johns Hopkins Hospital, Baltimore, Maryland 21205

A juvenile Siamese cat with severe, progressive motor disability was shown to have extensive neuronal degeneration caused by accumulation of GM1 ganglioside. Tissues from brain and kidney were markedly deficient in beta-galactosidase activity. The disease in this cat is thought to be inherited as an autosomal recessive trait, and is strikingly similar to juvenile GM1 gangliosidosis of children.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Adult-Onset Cerebellar Cortical Abiotrophy and Retinal Degeneration in a Domestic Shorthair Cat.
G. Barone, P. Foureman, and A. deLahunta (2002)
J. Am. Anim. Hosp. Assoc. 38, 51-54
   Abstract »    Full Text »    PDF »
Alterations in the Growth Hormone/Insulin-Like Growth Factor I Pathways in Feline GM1 Gangliosidosis.
N. R. Cox, N. E. Morrison, J. L. Sartin, F. C. Buonomo, B. Steele, and H. J. Baker (1999)
Endocrinology 140, 5698-5704
   Abstract »    Full Text »
Niemann-Pick disease: a genetic model in Siamese cats.
D. Wenger, M Sattler, T Kudoh, S. Snyder, and R. Kingston (1980)
Science 208, 1471-1473
   Abstract »    PDF »


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