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Science 19 November 1971:
Vol. 174. no. 4011, pp. 833 - 835
DOI: 10.1126/science.174.4011.833
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Articles

Anemic Stress as a Trigger of Myelogenous Leukemia in Rats Rendered Leukemia-Prone by X-ray

Joseph K. Gong 1

1 Department of Oral Biology, School of Dentistry, State University of New York at Buffalo, Buffalo 14214

All of the 128 Sprague-Dawley female rats bled two-thirds of the blood volume at 1, 2, or 3 months after irradiation (50, 170, or 350 roentgens) succumbed to leukemia by 16 months after bleeding. Some nonbled irradiated rats developed leukemia possibly as a result of triggering by a radiation-induced anemia. The threshold leukemogenic x-ray dose is probably below 25 roentgens. Elevated levels of basophils, neutrophils containing the "pseudo-Pelger" type nuclear anomaly, and myeloblasts exhibiting Auer rods seen in these animals were generally not found in earlier models of rat myelogenous leukemia.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Myeloid Leukemia: Does Blood Loss Increase the Incidence in X-irradiated Rats?.
M. A. Maloney, A. R. Margulis, and H. M. Patt (1973)
Science 180, 761-762
   PDF »
Anemic Stess as a Trigger of Myelogenous Leukemia in the Unirradiated RF Mouse.
J. K. Gong, P. G. Braunschweiger, and C. A. Glomski (1972)
Science 177, 274-276
   Abstract »    PDF »


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