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Science 12 November 1971:
Vol. 174. no. 4010, pp. 720 - 722
DOI: 10.1126/science.174.4010.720
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Articles

Ascorbic Acid: A Culture Requirement for Colony Formation by Mouse Plasmacytoma Cells

C. H. Park 1, D. E. Bergsagel 1, and E. A. McCulloch 1

1 Department of Medicine, University of Toronto, and Ontario Cancer Institute, Toronto 5, Canada

Plasmacytoma stem cells explanted from mice formed colonies in culture only in the presence of L-ascorbic acid; this vitamin was not needed for the formation of granulocytic colonies. Isomers of L-ascorbic acid with less antiscorbutic activity also promoted plasmacytoma colony formation, but less effectively. Other redox compounds without antiscorbutic activity and an antioxidant were ineffective.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Stromal Cell Oxidation: A Mechanism by Which Tumors Obtain Vitamin C.
D. B. Agus, J. C. Vera, and D. W. Golde (1999)
Cancer Res. 59, 4555-4558
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