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Science 22 October 1971:
Vol. 174. no. 4007, pp. 428 - 431
DOI: 10.1126/science.174.4007.428
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Articles

Social Behavior of Monkeys Selectively Depleted of Monoamines

D. E. Redmond Jr. 1, I. W. Maas 1, A. Kling 1, C. W. Graham 1, and H. Dekirmenjian 1

1 Illinois State Psychiatric Institute, Chicago 60612, and University of Illinois Medical School, Chicago

Initiated social interactions of Macaca speciosa are decreased during the period of treatment with alpha-methyl-p-tyrosine, an inhibitor of catecholamine synthesis. The treated animals maintained stable body weights and appeared to be healthy. Similar depletion of indoleamines with p-chlorophenylalanine does not change these same observed behaviors in spite of weight loss, hair loss, ataxia, and debilitation in some of the animals.


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