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Science 22 October 1971:
Vol. 174. no. 4007, pp. 424 - 426
DOI: 10.1126/science.174.4007.424
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Articles

Inhibition of Normal Growth by Chronic Administration of Dgr-9-Tetrahydrocannabinol

Frederick J. Manning 1, John H. Mcdonough Jr. 1, Timothy F. Elsmore 1, Charles Saller 1, and Frank J. Sodetz 1

1 Department of Experimental Psychology, Walter Reed Army Institute of Research, Washington, D. C. 20012

Body weight, food and water intake, and feces weight of 20 albino rats were recorded daily for 70 days. On days 11 to 40, 12 rats received behaviorally effective doses of Dgr-9-tetrahydrocannabinol, either orally or intraperitoneally. These rats ate significantly less than placebo-dosed controls during the treatment period, and gained significantly less weight. Food intake recovered in the 30-day posttreatment period, but the former drug group still weighed less than the controls on day 70. In addition, all rats who had received intraperitoneal injections of Dgr-9-tetrahydrocannabinol showed evidence of chronic diffuse nonsuppurative peritonitis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Dgr9-Tetrahydrocannabinol: Aversive Effects in Rat at High Doses.
T. F. Elsmore and G. V. Fletcher (1972)
Science 175, 911-912
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Science. ISSN 0036-8075 (print), 1095-9203 (online)