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Science 22 October 1971:
Vol. 174. no. 4007, pp. 422 - 424
DOI: 10.1126/science.174.4007.422
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Articles

Intestinal Secretion: Stimulation by Peptides

Gilbert O. Barbezt 1 and Morton I. Grossman 1

1 Wadsworth Hospital, Veterans Administration, Los Angeles, California 90073

Two peptides isolated from intestinal mucosa, vasoactive intestinal peptide, and gastric inhibitory peptide, stimulate small intestinal secretion in conscious dogs. Glucagon and pentagastrin also stimulate, but secretin and the octapetide of cholecystokinin do not. The stimulants may participate in regulation of intestinal secretion in health and in diseases with excessive secretion.


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