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Science 22 October 1971:
Vol. 174. no. 4007, pp. 408 - 410
DOI: 10.1126/science.174.4007.408
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Articles

Dopamine: Release from the Brain in vivo by Amantadine

Philip F. Von Vigtlander 1 and Kenneth E. Moore 1

1 Department of Pharmacology, Michigan State University, East Lansing 48823

After dopamine stores in the caudate nucleus of cats were labeled with [3H]dopamine, the ventricular system was perfused with artificial cerebrospinal fluid. The addition of amantadine to the perfusing fluid caused a doserelated increase in the concentrations of [3H]dopamine appearing in the perfusion effluent. Subthreshold concentrations of amantadine also enhanced the efflux of [3H]dopamine induced by electrical stimulation of the caudate nucleus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Amantadine Treatment of Fatigue Associated With Multiple Sclerosis.
R. A. Cohen and M. Fisher (1989)
Arch Neurol 46, 676-680
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