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Science 15 October 1971:
Vol. 174. no. 4006, pp. 295 - 297
DOI: 10.1126/science.174.4006.295
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Articles

Cyclic Adenosine Monophosphate: Function in Photoreceptors

W. H. Miller 1, R. E. Gorman 2, and M. W. Bitensky 2

1 Departments of Ophthalmology and Physiology, Yale Medical School, New Haven, Connecticut 06510
2 Department of Pathology, Yale Medical School

Inactivation of adenylate cyclase in outer segments of retinal photoreceptor cells is proportional to the bleaching of rhodopsin. Membranes of the outer segments also contain a particulate, light-insensitive phosphodiesterase of high specific activity. In electrophysiological experiments, application of cyclic adenosine monophosphate along with a methylxanthine mimics the effects of illumination on the photoreceptor cell of the compound eye of Limulus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Physiological Chemistry of the Eye.
G. W. Barber (1973)
Arch Ophthalmol 89, 236-255
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Optics and Visual Physiology.
I. M. Siegel (1972)
Arch Ophthalmol 88, 212-227
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Digitonin Effects on Photoreceptor Adenylate Cyclase.
M. W. Bitensky, R. E. Gorman, and W. H. Miller (1972)
Science 175, 1363-1364
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Rethinking the role of phosducin: Light-regulated binding of phosducin to 14-3-3 in rod inner segments.
K. Nakano, J. Chen, G. E. Tarr, T. Yoshida, J. M. Flynn, and M. W. Bitensky (2001)
PNAS 98, 4693-4698
   Abstract »    Full Text »    PDF »


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